It has been puzzling to me that every cancer patient I test for a Lyme infection turns out positive. My ongoing research on Lyme has focused in recent weeks on a mycoplasma that lies at the root of the disease. It appears to be the fundamental factor that severely depresses the immune system allowing the entire complex of pathogenic bacteria, fungi, parasites, and viruses to proliferate. A recent study shows that “chronic infection or colonization by mycoplasma(s) could gradually and significantly alter many biologic properties of mammalian host cells in culture, including induction of malignant transformation.”
Therefore, in those individuals with cancer, it is important to eliminate the Rife BX/BY “virus”, the Gregory “cancer virus”, the SV40 virus, and Lyme disease. Failing to do this sets the individual up for progression and/or recurrence of malignancy.
- Mycoplasma fermentans infection promotes immortalization of human peripheral blood mononuclear cells in culture.
Zhang S, Tsai S, Wu TT, Li B, Shih JW, Lo SC
Department of Infectious and Parasitic Diseases Pathology, American Registry of Pathology, Washington DC, USA. - Blood. 2004 Dec 15;104(13):4252-9. Epub 2004 Aug 26
Chronic infection or colonization by mycoplasma(s) could gradually and significantly alter many biologic properties of mammalian host cells in culture, including induction of malignant transformation. We examined effects of Mycoplasma fermentans infection on the continuing survival and immortality of human peripheral blood mononuclear cells (PBMCs) from healthy blood donors. Without specific supplemental growth factors, human PBMCs normally die rapidly, with few cells other than macrophages/monocytes surviving after 2 weeks in cultures. Only occasional Epstein-Barr virus (EBV)-positive B lymphocytes would continue to proliferate and undergo spontaneous immortalization. Our present study revealed that infection of human PBMCs in culture with the incognitus and PG18 strains of M fermentans, but surprisingly not with some other strains tested in parallel, markedly enhanced the rate of EBV-positive B lymphocytes to undergo immortalization (74% vs 17%). Compared with spontaneously immortalized PBMCs, the PBMCs immortalized in cultures infected with the mycoplasmas often had prominent karyotype changes with chromosomal loss, gain, or translocations. Furthermore, many of these immortalized B lymphocytes were found to be monoclonal in nature. The in vitro findings would be of relevance to lymphoproliferative disorders that occurred in patients with immune suppression. The mycoplasma-mediated promotional effect in cell immortalization and its potential clinical implications warrant further study.