Cancer is Always Associated with Viral and Bacterial Infections - Jeff Sutherland

How infection can lead to cancer

New MIT study offers comprehensive look at chemical andgenetic changes that occur as inflammation progressesto cancer.

Anne Trafton, MIT News Office

Endoscopic biopsy showing granulomatous inflammation of the colon in a case of Crohn’s disease.
IMAGE: WIKIPEDIA/NEPHRON

June 11, 2012

One of the biggest risk factors for liver, colon or stomach cancer is chronic inflammation of those organs, often caused by viral or bacterial infections. A new study from MIT
offers the most comprehensive look yet at how such infections provoke tissues into becoming cancerous.

The study, which is appearing in the online edition of Proceedings of the National Academy of Sciences the week of June 11, tracked a variety of genetic and chemical changes in the livers and colons of mice infected with Helicobacter hepaticus, a bacterium similar to Helicobacter pylori, which causes stomach ulcers and cancer in humans.

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