Skip to content

Jeff Sutherland

Twice the Energy with Half the Stress

Pseudoscientic: Over 1/3 of Medical Journal Papers Present False Conclusions

Reanalyses of Randomized Clinical Trial Data

Shanil Ebrahim, PhD1,2,3,4; Zahra N. Sohani, MSc2,5; Luis Montoya, DDS6; Arnav Agarwal, BSc7; Kristian Thorlund, PhD1,2; Edward J. Mills, PhD1,2,8; John P. A. Ioannidis, MD, DSc1,9,10,11

Importance  Reanalyses of randomized clinical trial (RCT) data may help the scientific community assess the validity of reported trial results.
Objectives  To identify published reanalyses of RCT data, to characterize methodological and other differences between the original trial and reanalysis, to evaluate the independence of authors performing the reanalyses, and to assess whether the reanalysis changed interpretations from the original article about the types or numbers of patients who should be treated.
Design  We completed an electronic search of MEDLINE from inception to March 9, 2014, to identify all published studies that completed a reanalysis of individual patient data from previously published RCTs addressing the same hypothesis as the original RCT. Four data extractors independently screened articles and extracted data.
Main Outcomes and Measures  Changes in direction and magnitude of treatment effect, statistical significance, and interpretation about the types or numbers of patients who should be treated.
Results  We identified 37 eligible reanalyses in 36 published articles, 5 of which were performed by entirely independent authors (2 based on publicly available data and 2 on data that were provided on request; data availability was unclear for 1). Reanalyses differed most commonly in statistical or analytical approaches (n = 18) and in definitions or measurements of the outcome of interest (n = 12). Four reanalyses changed the direction and 2 changed the magnitude of treatment effect, whereas 4 led to changes in statistical significance of findings. Thirteen reanalyses (35%) led to interpretations different from that of the original article, 3 (8%) showing that different patients should be treated; 1 (3%), that fewer patients should be treated; and 9 (24%), that more patients should be treated.
Conclusions and Relevance  A small number of reanalyses of RCTs have been published to date. Only a few were conducted by entirely independent authors. Thirty-five percent of published reanalyses led to changes in findings that implied conclusions different from those of the original article about the types and number of patients who should be treated.

desi mm story xxxhindiporn.net kyra dutt hot رسومات سكس alarab-porn.com نيك مرات العم khasi sex video indianpornanal.com find your milf قصص سكس مثيرة جدا abdulaporn.info السكس بكس jennifer kotwal tubepornmix.info riding porn
نيك الخدامه freesextube.org مقاطع سكس مترجم punjabi sexy blue video pornhostel.info x vodeos sexy video open sex sexofvideo.info xvideos2 india جنس فلاحى pornovuku.info نسوان ملط sunny leone 4x pakistanixxx.org indian teen nude
desi videos xnxx pornvideox.mobi www desibest indian xnxx latest pornerbros.mobi blue film mp3 youtube sunita baby tubexo.info kamalika chanda instagram jones cup live teleseryeonline.com kmjs latest episode xxxbunkers porndu.net spark porn