Mycoplasma are common coinfections in Lyme disease. They are very small bacteria without cell walls, hard to detect, and difficult to eliminate. They can be passed by insect bites, physical contact, food, or airborne modalities. Virtually everyone has some mycoplasma infections, particularly ureaplasma through sexual contact. They can cause all the symptoms of Lyme disease and may be at the root of many autoimmune disorders. Version 2.0 has doubled the number of frequency sets for mycoplasma and specifically identified many species of mycoplasma. Mycoplasma hominis is so common it has been broken out as a separate file.